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BMCBI
2010
163views more  BMCBI 2010»
14 years 10 months ago
Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity
Background: Computational comparison of two protein structures is the starting point of many methods that build on existing knowledge, such as structure modeling (including modeli...
Zong Hong Zhang, Hwee Kuan Lee, Ivana Mihalek
BMCBI
2010
124views more  BMCBI 2010»
14 years 10 months ago
Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated
Background: Large datasets of protein interactions provide a rich resource for the discovery of Short Linear Motifs (SLiMs) that recur in unrelated proteins. However, existing met...
Norman E. Davey, Richard J. Edwards, Denis C. Shie...
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BMCBI
2010
126views more  BMCBI 2010»
14 years 10 months ago
Cgaln: fast and space-efficient whole-genome alignment
Background: Whole-genome sequence alignment is an essential process for extracting valuable information about the functions, evolution, and peculiarities of genomes under investig...
Ryuichiro Nakato, Osamu Gotoh
BMCBI
2010
102views more  BMCBI 2010»
14 years 10 months ago
Missing genes in the annotation of prokaryotic genomes
Background: Protein-coding gene detection in prokaryotic genomes is considered a much simpler problem than in intron-containing eukaryotic genomes. However there have been reports...
Andrew S. Warren, Jeremy S. Archuleta, Wu-chun Fen...
BMCBI
2010
120views more  BMCBI 2010»
14 years 10 months ago
Short clones or long clones? A simulation study on the use of paired reads in metagenomics
Background: Metagenomics is the study of environmental samples using sequencing. Rapid advances in sequencing technology are fueling a vast increase in the number and scope of met...
Suparna Mitra, Max Schubach, Daniel H. Huson