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BMCBI
2010
243views more  BMCBI 2010»
14 years 10 months ago
Comparative study of unsupervised dimension reduction techniques for the visualization of microarray gene expression data
Background: Visualization of DNA microarray data in two or three dimensional spaces is an important exploratory analysis step in order to detect quality issues or to generate new ...
Christoph Bartenhagen, Hans-Ulrich Klein, Christia...
BMCBI
2010
102views more  BMCBI 2010»
14 years 10 months ago
Peptide binding predictions for HLA DR, DP and DQ molecules
Background: MHC class II binding predictions are widely used to identify epitope candidates in infectious agents, allergens, cancer and autoantigens. The vast majority of predicti...
Peng Wang, John Sidney, Yohan Kim, Alessandro Sett...
BMCBI
2008
89views more  BMCBI 2008»
14 years 10 months ago
Increasing the efficiency of bacterial transcription simulations: When to exclude the genome without loss of accuracy
Background: Simulating the major molecular events inside an Escherichia coli cell can lead to a very large number of reactions that compose its overall behaviour. Not only should ...
Marco A. J. Iafolla, Guang Qiang Dong, David R. Mc...
BMCBI
2007
112views more  BMCBI 2007»
14 years 10 months ago
Selecting dissimilar genes for multi-class classification, an application in cancer subtyping
Background: Gene expression microarray is a powerful technology for genetic profiling diseases and their associated treatments. Such a process involves a key step of biomarker ide...
Zhipeng Cai, Randy Goebel, Mohammad R. Salavatipou...
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BMCBI
2007
94views more  BMCBI 2007»
14 years 10 months ago
A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays
Background: Affymetrix SNP arrays can interrogate thousands of SNPs at the same time. This allows us to look at the genomic content of cancer cells and to investigate the underlyi...
Philippe Lamy, Claus L. Andersen, Lars Dyrskjot, N...