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BMCBI
2010
118views more  BMCBI 2010»
14 years 9 months ago
Towards realistic benchmarks for multiple alignments of non-coding sequences
Background: With the continued development of new computational tools for multiple sequence alignment, it is necessary today to develop benchmarks that aid the selection of the mo...
Jaebum Kim, Saurabh Sinha
ALMOB
2007
151views more  ALMOB 2007»
14 years 9 months ago
Local sequence alignments statistics: deviations from Gumbel statistics in the rare-event tail
Background: The optimal score for ungapped local alignments of infinitely long random sequences is known to follow a Gumbel extreme value distribution. Less is known about the imp...
Stefan Wolfsheimer, Bernd Burghardt, Alexander K. ...
BMCBI
2006
140views more  BMCBI 2006»
14 years 9 months ago
MACSIMS : multiple alignment of complete sequences information management system
Background: In the post-genomic era, systems-level studies are being performed that seek to explain complex biological systems by integrating diverse resources from fields such as...
Julie D. Thompson, Arnaud Muller, Andrew M. Waterh...
JCB
2008
106views more  JCB 2008»
14 years 9 months ago
Statistics of Random Protein Superpositions: p-Values for Pairwise Structure Alignment
Quantification of statistical significance is essential for the interpretation of protein structural similarity. To address this, a random model for protein structure comparison w...
James O. Wrabl, Nick V. Grishin
PAMI
2011
14 years 4 months ago
Approximately Global Optimization for Robust Alignment of Generalized Shapes
—In this paper, we introduce a novel method to solve shape alignment problems. We use gray-scale “images” to represent source shapes, and propose a novel two-component Gaussi...
Hongsheng Li, Tian Shen, Xiaolei Huang