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BMCBI
2007
120views more  BMCBI 2007»
14 years 9 months ago
Quantitative sequence-function relationships in proteins based on gene ontology
Background: The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs share function...
Vineet Sangar, Daniel J. Blankenberg, Naomi Altman...
RECOMB
2005
Springer
15 years 10 months ago
Using Multiple Alignments to Improve Gene Prediction
The multiple species de novo gene prediction problem can be stated as follows: given an alignment of genomic sequences from two or more organisms, predict the location and structur...
Samuel S. Gross, Michael R. Brent
BMCBI
2008
111views more  BMCBI 2008»
14 years 9 months ago
SciDBMaker: new software for computer-aided design of specialized biological databases
Background: The exponential growth of research in molecular biology has brought concomitant proliferation of databases for stocking its findings. A variety of protein sequence dat...
Riadh Hammami, Abdelmajid Zouhir, Karim Naghmouchi...
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BMCBI
2007
59views more  BMCBI 2007»
14 years 9 months ago
Environment specific substitution tables for thermophilic proteins
Background: Thermophilic organisms are able to live at high temperatures ranging from 50 to > 100°C. Their proteins must be sufficiently stable to function under these extreme...
K. Mizuguchi, M. Sele, Maria Vittoria Cubellis
BMCBI
2008
149views more  BMCBI 2008»
14 years 9 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal