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BMCBI
2006
131views more  BMCBI 2006»
15 years 3 months ago
SIMAGE: simulation of DNA-microarray gene expression data
Background: Simulation of DNA-microarray data serves at least three purposes: (i) optimizing the design of an intended DNA microarray experiment, (ii) comparing existing pre-proce...
Casper J. Albers, Ritsert C. Jansen, Jan Kok, Osca...
BMCBI
2006
106views more  BMCBI 2006»
15 years 3 months ago
Methodological study of affine transformations of gene expression data with proposed robust non-parametric multi-dimensional nor
Background: Low-level processing and normalization of microarray data are most important steps in microarray analysis, which have profound impact on downstream analysis. Multiple ...
Henrik Bengtsson, Ola Hössjer
BMCBI
2006
120views more  BMCBI 2006»
15 years 3 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner
BMCBI
2006
145views more  BMCBI 2006»
15 years 3 months ago
GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
Kazuharu Arakawa, Yohei Yamada, Kosaku Shinoda, Yo...
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BMCBI
2006
109views more  BMCBI 2006»
15 years 3 months ago
Integrated analysis of gene expression by association rules discovery
Background: Microarray technology is generating huge amounts of data about the expression level of thousands of genes, or even whole genomes, across different experimental conditi...
Pedro Carmona-Saez, Monica Chagoyen, Andrés...
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