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GECCO
2003
Springer
128views Optimization» more  GECCO 2003»
15 years 5 months ago
Evolving Consensus Sequence for Multiple Sequence Alignment with a Genetic Algorithm
In this paper we present an approach that evolves the consensus sequence [25] for multiple sequence alignment (MSA) with genetic algorithm (GA). We have developed an encoding schem...
Conrad Shyu, James A. Foster
112
Voted
NAR
1998
86views more  NAR 1998»
15 years 6 days ago
Pfam: multiple sequence alignments and HMM-profiles of protein domains
Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignm...
Erik L. L. Sonnhammer, Sean R. Eddy, Ewan Birney, ...
102
Voted
ISCAPDCS
2007
15 years 2 months ago
PARALLEL-TCOFFEE: A parallel multiple sequence aligner
In this paper we present a parallel implementation of T–Coffee — a widely used multiple sequence alignment package. Our software supports a majority of options provided by the...
Jaroslaw Zola, Xiao Yang, Adrian Rospondek, Sriniv...
86
Voted
ACL
1998
15 years 1 months ago
Alignment of Multiple Languages for Historical Comparison
An essential step in comparative reconstruction is to align corresponding phonological segments in the words being compared. To do this, one must search among huge numbers of pote...
Michael A. Covington
108
Voted
BMCBI
2007
142views more  BMCBI 2007»
15 years 20 days ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...