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» Multiple alignment by aligning alignments
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125
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BMCBI
2004
96views more  BMCBI 2004»
15 years 12 days ago
Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
Olga V. Matveeva, Brian T. Foley, Vladimir A. Nemt...
95
Voted
RECOMB
1997
Springer
15 years 4 months ago
A branch-and-cut algorithm for multiple sequence alignment
Multiple sequence alignment is an important problem in computational biology. We study the Maximum Trace formulation introduced by Kececioglu [?]. We first phrase the problem in ...
Knut Reinert, Hans-Peter Lenhof, Petra Mutzel, Kur...
102
Voted
JPDC
2006
112views more  JPDC 2006»
15 years 15 days ago
Large scale multiple sequence alignment with simultaneous phylogeny inference
Multiple sequence alignment (MSA) and phylogenetic tree reconstruction are one of the most important problems in the computational biology. While both these problems are of great ...
Gilles Parmentier, Denis Trystram, Jaroslaw Zola
BIOINFORMATICS
2005
75views more  BIOINFORMATICS 2005»
15 years 14 days ago
DbW: automatic update of a functional family-specific multiple alignment
: Recent advances in gene sequencing have provided complete sequence information for a number of genomes and as a result the amount of data in the sequence databases is growing at ...
Veronique Prigent, Jean-Claude Thierry, Olivier Po...
113
Voted
BMCBI
2006
117views more  BMCBI 2006»
15 years 18 days ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala