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» Multiplicative Background Risk
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89
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BMCBI
2010
116views more  BMCBI 2010»
15 years 28 days ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
105
Voted
BMCBI
2010
95views more  BMCBI 2010»
15 years 28 days ago
Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso
Background: Single nucleotide polymorphism (SNP) based association studies aim at identifying SNPs associated with phenotypes, for example, complex diseases. The associated SNPs m...
Can Yang, Xiang Wan, Qiang Yang, Hong Xue, Weichua...
108
Voted
ARTMED
2006
86views more  ARTMED 2006»
15 years 26 days ago
Spatiotemporal reasoning about epidemiological data
Objective. In this article, we propose new methods to visualize and reason about spatiotemporal epidemiological data. Background. Efficient computerized reasoning about epidemics ...
Peter Z. Revesz, Shasha Wu
114
Voted
BMCBI
2007
138views more  BMCBI 2007»
15 years 24 days ago
A novel Bayesian approach to quantify clinical variables and to determine their spectroscopic counterparts in 1H NMR metabonomic
Background: A key challenge in metabonomics is to uncover quantitative associations between multidimensional spectroscopic data and biochemical measures used for disease risk asse...
Aki Vehtari, Ville-Petteri Mäkinen, Pasi Soin...
BMCBI
2005
157views more  BMCBI 2005»
15 years 21 days ago
Decision Forest Analysis of 61 Single Nucleotide Polymorphisms in a Case-Control Study of Esophageal Cancer; a novel method
Background: Systematic evaluation and study of single nucleotide polymorphisms (SNPs) made possible by high throughput genotyping technologies and bioinformatics promises to provi...
Qian Xie, Luke D. Ratnasinghe, Huixiao Hong, Roger...