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» Multiplicative Background Risk
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SIGIR
2002
ACM
15 years 13 days ago
Two-stage language models for information retrieval
The optimal settings of retrieval parameters often depend on both the document collection and the query, and are usually found through empirical tuning. In this paper, we propose ...
ChengXiang Zhai, John D. Lafferty
BMCBI
2010
176views more  BMCBI 2010»
14 years 10 months ago
Haplotype association analyses in resources of mixed structure using Monte Carlo testing
Background: Genomewide association studies have resulted in a great many genomic regions that are likely to harbor disease genes. Thorough interrogation of these specific regions ...
Ryan Abo, Jathine Wong, Alun Thomas, Nicola J. Cam...
BMCBI
2005
134views more  BMCBI 2005»
15 years 21 days ago
Ancestral sequence alignment under optimal conditions
Background: Multiple genome alignment is an important problem in bioinformatics. An important subproblem used by many multiple alignment approaches is that of aligning two multipl...
Alexander K. Hudek, Daniel G. Brown 0001
91
Voted
BMCBI
2008
105views more  BMCBI 2008»
15 years 28 days ago
Using the longest significance run to estimate region-specific p-values in genetic association mapping studies
Background: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increas...
Ie-Bin Lian, Yi-Hsien Lin, Ying-Chao Lin, Hsin-Cho...
107
Voted
BMCBI
2007
123views more  BMCBI 2007»
15 years 28 days ago
PedGenie: meta genetic association testing in mixed family and case-control designs
Background-: PedGenie software, introduced in 2006, includes genetic association testing of cases and controls that may be independent or related (nuclear families or extended ped...
Karen Curtin, Jathine Wong, Kristina Allen-Brady, ...