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96
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BMCBI
2010
154views more  BMCBI 2010»
15 years 26 days ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...
98
Voted
BMCBI
2010
137views more  BMCBI 2010»
15 years 26 days ago
Biana: a software framework for compiling biological interactions and analyzing networks
Background: The analysis and usage of biological data is hindered by the spread of information across multiple repositories and the difficulties posed by different nomenclature sy...
Javier Garcia-Garcia, Emre Guney, Ramon Aragues, J...
121
Voted
BMCBI
2010
154views more  BMCBI 2010»
15 years 26 days ago
An eScience-Bayes strategy for analyzing omics data
Background: The omics fields promise to revolutionize our understanding of biology and biomedicine. However, their potential is compromised by the challenge to analyze the huge da...
Martin Eklund, Ola Spjuth, Jarl E. S. Wikberg
107
Voted
BMCBI
2010
130views more  BMCBI 2010»
15 years 26 days ago
MLPAinter for MLPA interpretation: an integrated approach for the analysis, visualisation and data management of Multiplex Ligat
Background: Multiplex Ligation-Dependent Probe Amplification (MLPA) is an application that can be used for the detection of multiple chromosomal aberrations in a single experiment...
Ronald van Eijk, Paul H. C. Eilers, Remco Natt&eac...
BMCBI
2010
162views more  BMCBI 2010»
15 years 26 days ago
SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping
Background: PCR-restriction fragment length polymorphism (RFLP) assay is a cost-effective method for SNP genotyping and mutation detection, but the manual mining for restriction e...
Hsueh-Wei Chang, Yu-Huei Cheng, Li-Yeh Chuang, Che...