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113
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BMCBI
2006
123views more  BMCBI 2006»
15 years 24 days ago
SBEAMS-Microarray: database software supporting genomic expression analyses for systems biology
Background: The biological information in genomic expression data can be understood, and computationally extracted, in the context of systems of interacting molecules. The automat...
Bruz Marzolf, Eric W. Deutsch, Patrick Moss, David...
100
Voted
BMCBI
2006
130views more  BMCBI 2006»
15 years 24 days ago
4SALE - A tool for synchronous RNA sequence and secondary structure alignment and editing
Background: In sequence analysis the multiple alignment builds the fundament of all proceeding analyses. Errors in an alignment could strongly influence all succeeding analyses an...
Philipp N. Seibel, Tobias Müller, Thomas Dand...
126
Voted
BMCBI
2007
113views more  BMCBI 2007»
15 years 22 days ago
Statistical power of phylo-HMM for evolutionarily conserved element detection
Background: An important goal of comparative genomics is the identification of functional elements through conservation analysis. Phylo-HMM was recently introduced to detect conse...
Xiaodan Fan, Jun Zhu, Eric E. Schadt, Jun S. Liu
82
Voted
BMCBI
2007
105views more  BMCBI 2007»
15 years 22 days ago
Extended analysis of benchmark datasets for Agilent two-color microarrays
Background: As part of its broad and ambitious mission, the MicroArray Quality Control (MAQC) project reported the results of experiments using External RNA Controls (ERCs) on fiv...
Kathleen F. Kerr
83
Voted
BMCBI
2007
77views more  BMCBI 2007»
15 years 22 days ago
The reactive metabolite target protein database (TPDB) - a web-accessible resource
Background: The toxic effects of many simple organic compounds stem from their biotransformation to chemically reactive metabolites which bind covalently to cellular proteins. To ...
Robert P. Hanzlik, Yakov M. Koen, Bhargav Theertha...