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BMCBI
2007
175views more  BMCBI 2007»
15 years 23 days ago
Apollo2Go: a web service adapter for the Apollo genome viewer to enable distributed genome annotation
Background: Apollo, a genome annotation viewer and editor, has become a widely used genome annotation and visualization tool for distributed genome annotation projects. When using...
Kathrin Klee, Rebecca Ernst, Manuel Spannagl, Klau...
87
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BMCBI
2008
94views more  BMCBI 2008»
15 years 23 days ago
Conserved co-expression for candidate disease gene prioritization
Background: Genes that are co-expressed tend to be involved in the same biological process. However, co-expression is not a very reliable predictor of functional links between gen...
Martin Oti, Jeroen van Reeuwijk, Martijn A. Huynen...
94
Voted
BMCBI
2007
109views more  BMCBI 2007»
15 years 23 days ago
Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint
Background: Structural genomics initiatives were established with the aim of solving protein structures on a large-scale. For many initiatives, such as the Protein Structure Initi...
Russell L. Marsden, Tony A. Lewis, Christine A. Or...
104
Voted
BMCBI
2007
135views more  BMCBI 2007»
15 years 23 days ago
Sequence similarity is more relevant than species specificity in probabilistic backtranslation
Background: Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module....
Alfredo Ferro, Rosalba Giugno, Giuseppe Pigola, Al...
109
Voted
BMCBI
2007
142views more  BMCBI 2007»
15 years 23 days ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...