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» Multiplicative Background Risk
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BMCBI
2008
179views more  BMCBI 2008»
15 years 18 days ago
Improving the power for detecting overlapping genes from multiple DNA microarray-derived gene lists
Background: In DNA microarray gene expression profiling studies, a fundamental task is to extract statistically significant genes that meet certain research hypothesis. Currently,...
Xutao Deng, Jun Xu, Charles Wang
102
Voted
BMCBI
2008
122views more  BMCBI 2008»
15 years 18 days ago
Grammar-based distance in progressive multiple sequence alignment
Background: We propose a multiple sequence alignment (MSA) algorithm and compare the alignment-quality and execution-time of the proposed algorithm with that of existing algorithm...
David J. Russell, Hasan H. Otu, Khalid Sayood
BMCBI
2008
154views more  BMCBI 2008»
15 years 18 days ago
Bayesian models and meta analysis for multiple tissue gene expression data following corticosteroid administration
Background: This paper addresses key biological problems and statistical issues in the analysis of large gene expression data sets that describe systemic temporal response cascade...
Yulan Liang, Arpad Kelemen
97
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BMCBI
2006
127views more  BMCBI 2006»
15 years 16 days ago
PathogenMIPer: a tool for the design of molecular inversion probes to detect multiple pathogens
Background: Here we describe PathogenMIPer, a software program for designing molecular inversion probe (MIP) oligonucleotides for use in pathogen identification and detection. The...
Sreedevi Thiyagarajan, Miloslav Karhanek, Michael ...
109
Voted
BMCBI
2005
93views more  BMCBI 2005»
15 years 11 days ago
Multiple sequence alignment accuracy and evolutionary distance estimation
Background: Sequence alignment is a common tool in bioinformatics and comparative genomics. It is generally assumed that multiple sequence alignment yields better results than pai...
Michael S. Rosenberg