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» Multiplicative Background Risk
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126
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BMCBI
2007
219views more  BMCBI 2007»
15 years 29 days ago
MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments
Background: Integration of multiple results from Quantitative Trait Loci (QTL) studies is a key point to understand the genetic determinism of complex traits. Up to now many effor...
Jean-Baptiste Veyrieras, Bruno Goffinet, Alain Cha...
114
Voted
BMCBI
2006
92views more  BMCBI 2006»
15 years 27 days ago
A jumping profile Hidden Markov Model and applications to recombination sites in HIV and HCV genomes
Background: Jumping alignments have recently been proposed as a strategy to search a given multiple sequence alignment A against a database. Instead of comparing a database sequen...
Anne-Kathrin Schultz, Ming Zhang, Thomas Leitner, ...
104
Voted
BMCBI
2005
104views more  BMCBI 2005»
15 years 22 days ago
Wildfire: distributed, Grid-enabled workflow construction and execution
Background: We observe two trends in bioinformatics: (i) analyses are increasing in complexity, often requiring several applications to be run as a workflow; and (ii) multiple CPU...
Francis Tang, Ching Lian Chua, Liang-Yoong Ho, Yun...
BMCBI
2004
177views more  BMCBI 2004»
15 years 21 days ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
88
Voted
BMCBI
2006
108views more  BMCBI 2006»
15 years 27 days ago
Probe set algorithms: is there a rational best bet?
Affymetrix microarrays have become a standard experimental platform for studies of mRNA expression profiling. Their success is due, in part, to the multiple oligonucleotide featur...
Jinwook Seo, Eric P. Hoffman