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BMCBI
2010
136views more  BMCBI 2010»
14 years 9 months ago
Bias correction and Bayesian analysis of aggregate counts in SAGE libraries
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
Russell L. Zaretzki, Michael A. Gilchrist, William...
BMCBI
2007
168views more  BMCBI 2007»
14 years 9 months ago
GOSim - an R-package for computation of information theoretic GO similarities between terms and gene products
Background: With the increased availability of high throughput data, such as DNA microarray data, researchers are capable of producing large amounts of biological data. During the...
Holger Fröhlich, Nora Speer, Annemarie Poustk...
BMCBI
2006
119views more  BMCBI 2006»
14 years 9 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs
BMCBI
2005
106views more  BMCBI 2005»
14 years 9 months ago
A multistep bioinformatic approach detects putative regulatory elements in gene promoters
Background: Searching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge ...
Stefania Bortoluzzi, Alessandro Coppe, Andrea Biso...
GECCO
2008
Springer
175views Optimization» more  GECCO 2008»
14 years 10 months ago
Using differential evolution for symbolic regression and numerical constant creation
One problem that has plagued Genetic Programming (GP) and its derivatives is numerical constant creation. Given a mathematical formula expressed as a tree structure, the leaf node...
Brian M. Cerny, Peter C. Nelson, Chi Zhou