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BMCBI
2010
124views more  BMCBI 2010»
14 years 10 months ago
Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: Transcriptional dynamics and regu
Background: Comprehensively understanding corticosteroid pharmacogenomic effects is an essential step towards an insight into the underlying molecular mechanisms for both benefici...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
BMCBI
2008
121views more  BMCBI 2008»
14 years 10 months ago
Stability of gene contributions and identification of outliers in multivariate analysis of microarray data
Background: Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages com...
Florent Baty, Daniel Jaeger, Frank Preiswerk, Mart...
DILS
2005
Springer
15 years 3 months ago
Hybrid Integration of Molecular-Biological Annotation Data
: We present a new approach to integrate annotation data from public sources for the expression analysis of genes and proteins. Expression data is materialized in a data warehouse ...
Toralf Kirsten, Hong Hai Do, Christine Körner...
BMCBI
2006
138views more  BMCBI 2006»
14 years 10 months ago
Determination of strongly overlapping signaling activity from microarray data
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
Ghislain Bidaut, Karsten Suhre, Jean-Michel Claver...
GCB
2008
Springer
103views Biometrics» more  GCB 2008»
14 years 11 months ago
Utilizing Promoter Pair Orientations for HMM-based Analysis of ChIP-chip Data
: Array-based analysis of chromatin immunoprecipitation data (ChIP-chip) is a powerful technique for identifying DNA target regions of individual transcription factors. Here, we pr...
Michael Seifert, Jens Keilwagen, Marc Strickert, I...