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» Neural Networks for Determining Protein Specificity and Mult...
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BMCBI
2008
145views more  BMCBI 2008»
13 years 6 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2008
100views more  BMCBI 2008»
13 years 6 months ago
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen p
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherap...
Guanglan Zhang, Asif M. Khan, Kellathur N. Sriniva...
IWANN
2009
Springer
14 years 25 days ago
Efficient Exact Pattern-Matching in Proteomic Sequences
Abstract. This paper proposes a novel algorithm for complete exact patternmatching focusing the specificities of protein sequences (alphabet of 20 symbols) but, also highly efficie...
Sérgio A. D. Deusdado, Paulo M. M. Carvalho
BMCBI
2002
133views more  BMCBI 2002»
13 years 6 months ago
Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model app
Background: Most profile and motif databases strive to classify protein sequences into a broad spectrum of protein families. The next step of such database studies should include ...
Kevin Truong, Mitsuhiko Ikura
WABI
2010
Springer
167views Bioinformatics» more  WABI 2010»
13 years 4 months ago
Quantifying the Strength of Natural Selection of a Motif Sequence
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Chen-Hsiang Yeang