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BMCBI
2006
108views more  BMCBI 2006»
15 years 1 months ago
Gene function classification using Bayesian models with hierarchy-based priors
We investigate the application of hierarchical classification schemes to the annotation of gene function based on several characteristics of protein sequences including phylogenic ...
Babak Shahbaba, Radford M. Neal
CORR
2007
Springer
130views Education» more  CORR 2007»
15 years 1 months ago
Lagrangian Relaxation for MAP Estimation in Graphical Models
Abstract— We develop a general framework for MAP estimation in discrete and Gaussian graphical models using Lagrangian relaxation techniques. The key idea is to reformulate an in...
Jason K. Johnson, Dmitry M. Malioutov, Alan S. Wil...
BMCBI
2004
151views more  BMCBI 2004»
15 years 1 months ago
Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics
Background: The general problem of RNA secondary structure prediction under the widely used thermodynamic model is known to be NP-complete when the structures considered include a...
Jens Reeder, Robert Giegerich
GIS
2002
ACM
15 years 1 months ago
A road network embedding technique for k-nearest neighbor search in moving object databases
A very important class of queries in GIS applications is the class of K-Nearest Neighbor queries. Most of the current studies on the K-Nearest Neighbor queries utilize spatial ind...
Cyrus Shahabi, Mohammad R. Kolahdouzan, Mehdi Shar...
OOPSLA
2010
Springer
14 years 12 months ago
Random testing for higher-order, stateful programs
Testing is among the most effective tools available for finding bugs. Still, we know of no automatic technique for generating test cases that expose bugs involving a combination ...
Casey Klein, Matthew Flatt, Robert Bruce Findler