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BMCBI
2010
123views more  BMCBI 2010»
14 years 10 months ago
An improved classification of G-protein-coupled receptors using sequence-derived features
Background: G-protein-coupled receptors (GPCRs) play a key role in diverse physiological processes and are the targets of almost two-thirds of the marketed drugs. The 3 D structur...
Zhen-Ling Peng, Jian-Yi Yang, Xin Chen
BMCBI
2007
134views more  BMCBI 2007»
14 years 10 months ago
Efficient pairwise RNA structure prediction using probabilistic alignment constraints in Dynalign
Background: Joint alignment and secondary structure prediction of two RNA sequences can significantly improve the accuracy of the structural predictions. Methods addressing this p...
Arif Ozgun Harmanci, Gaurav Sharma, David H. Mathe...
BMCBI
2007
176views more  BMCBI 2007»
14 years 10 months ago
Correlation-maximizing surrogate gene space for visual mining of gene expression patterns in developing barley endosperm tissue
Background: Micro- and macroarray technologies help acquire thousands of gene expression patterns covering important biological processes during plant ontogeny. Particularly, fait...
Marc Strickert, Nese Sreenivasulu, Björn Usad...
BMCBI
2011
14 years 4 months ago
Taxon ordering in phylogenetic trees: a workbench test
Background: Phylogenetic trees are an important tool for representing evolutionary relationships among organisms. In a phylogram or chronogram, the ordering of taxa is not conside...
Francesco Cerutti, Luigi Bertolotti, Tony L. Goldb...
BMCBI
2008
148views more  BMCBI 2008»
14 years 10 months ago
Critical assessment of alignment procedures for LC-MS proteomics and metabolomics measurements
Background: Liquid chromatography coupled to mass spectrometry (LC-MS) has become a prominent tool for the analysis of complex proteomics and metabolomics samples. In many applica...
Eva Lange, Ralf Tautenhahn, Steffen Neumann, Cleme...