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BMCBI
2010
108views more  BMCBI 2010»
15 years 7 months ago
Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of h
Background: A major goal of the analysis of high-dimensional RNA expression data from tumor tissue is to identify prognostic signatures for discriminating patient subgroups. For t...
Birte Hellwig, Jan G. Hengstler, Marcus Schmidt, M...
BMCBI
2010
165views more  BMCBI 2010»
15 years 7 months ago
Bayesian integrated modeling of expression data: a case study on RhoG
Background: DNA microarrays provide an efficient method for measuring activity of genes in parallel and even covering all the known transcripts of an organism on a single array. T...
Rashi Gupta, Dario Greco, Petri Auvinen, Elja Arja...
BMCBI
2010
109views more  BMCBI 2010»
15 years 7 months ago
Structural alphabets derived from attractors in conformational space
Background: The hierarchical and partially redundant nature of protein structures justifies the definition of frequently occurring conformations of short fragments as `states'...
Alessandro Pandini, Arianna Fornili, Jens Kleinjun...
BMCBI
2010
172views more  BMCBI 2010»
15 years 7 months ago
Comparison of evolutionary algorithms in gene regulatory network model inference
Background: The evolution of high throughput technologies that measure gene expression levels has created a data base for inferring GRNs (a process also known as reverse engineeri...
Alina Sîrbu, Heather J. Ruskin, Martin Crane
BMCBI
2010
117views more  BMCBI 2010»
15 years 7 months ago
Automatic, context-specific generation of Gene Ontology slims
Background: The use of ontologies to control vocabulary and structure annotation has added value to genomescale data, and contributed to the capture and re-use of knowledge across...
Melissa J. Davis, Muhammad Shoaib B. Sehgal, Mark ...
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