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146
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BMCBI
2011
14 years 10 months ago
Sequential Interim Analyses of Survival Data in DNA Microarray Experiments
Background: Discovery of biomarkers that are correlated with therapy response and thus with survival is an important goal of medical research on severe diseases, e.g. cancer. Freq...
Andreas Leha, Tim Beißbarth, Klaus Jung
151
Voted
BMCBI
2011
14 years 7 months ago
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in Bre
Background: Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biologi...
Hiroko K. Solvang, Ole Christian Lingjærde, ...
124
Voted
BMCBI
2011
14 years 7 months ago
LAVA: An Open-Source Approach To Designing LAMP (Loop-Mediated Isothermal Amplification) DNA Signatures
Background: We developed an extendable open-source Loop-mediated isothermal AMPlification (LAMP) signature design program called LAVA (LAMP Assay Versatile Analysis). LAVA was cre...
Clinton Torres, Elizabeth A. Vitalis, Brian R. Bak...
146
Voted
BMCBI
2011
14 years 7 months ago
Smith-Waterman Peak Alignment for Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry
Background: Comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC × GCMS) is a powerful technique which has gained increasing attention over the las...
Seongho Kim, Imhoi Koo, Aiqin Fang, Xiang Zhang
129
Voted
DLOG
2011
14 years 7 months ago
Analysing Multiple Versions of an Ontology: A Study of the NCI Thesaurus
The detection of changes between OWL ontologies is an important service for ontology engineering. There are several approaches to this problem, both syntactic and semantic. A purel...
Rafael S. Gonçalves, Bijan Parsia, Ulrike S...
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