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121
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BMCBI
2010
15 years 3 months ago
2010
Background: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostabilit...
142
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BMCBI
2007
15 years 3 months ago
2007
Background: High content screening (HCS) is a powerful method for the exploration of cellular signalling and morphology that is rapidly being adopted in cancer research. HCS uses ...
117
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BMCBI
2010
15 years 3 months ago
2010
Background: PDZ domains mediate protein-protein interactions involved in important biological processes through the recognition of short linear motifs in their target proteins. Tw...
108
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BMCBI
2010
15 years 3 months ago
2010
Background: MHC class II binding predictions are widely used to identify epitope candidates in infectious agents, allergens, cancer and autoantigens. The vast majority of predicti...
116
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BMCBI
2007
15 years 3 months ago
2007
Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...