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BMCBI
2008
129views more  BMCBI 2008»
14 years 11 months ago
A unified approach to false discovery rate estimation
Background: False discovery rate (FDR) methods play an important role in analyzing highdimensional data. There are two types of FDR, tail area-based FDR and local FDR, as well as ...
Korbinian Strimmer
BMCBI
2007
114views more  BMCBI 2007»
14 years 11 months ago
False occurrences of functional motifs in protein sequences highlight evolutionary constraints
Background: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a nume...
Allegra Via, Pier Federico Gherardini, Enrico Ferr...
BMCBI
2008
130views more  BMCBI 2008»
14 years 11 months ago
FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
Background: Drug discovery and chemical biology are exceedingly complex and demanding enterprises. In recent years there are been increasing awareness about the importance of pred...
David Lagorce, Olivier Sperandio, Hervé Gal...
BMCBI
2008
129views more  BMCBI 2008»
14 years 11 months ago
An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments
Background: Metabolic fluxes provide invaluable insight on the integrated response of a cell to environmental stimuli or genetic modifications. Current computational methods for e...
Ari Rantanen, Juho Rousu, Paula Jouhten, Nicola Za...
BMCBI
2008
83views more  BMCBI 2008»
14 years 11 months ago
Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells
Background: Microarray technology has unveiled transcriptomic differences among tumors of various phenotypes, and, especially, brought great progress in molecular understanding of...
Atsushi Niida, Andrew D. Smith, Seiya Imoto, Shuic...