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117
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BMCBI
2010
112views more  BMCBI 2010»
15 years 3 months ago
SeqAnt: A web service to rapidly identify and annotate DNA sequence variations
Background: The enormous throughput and low cost of second-generation sequencing platforms now allow research and clinical geneticists to routinely perform single experiments that...
Amol Carl Shetty, Prashanth Athri, Kajari Mondal, ...
BMCBI
2007
156views more  BMCBI 2007»
15 years 3 months ago
Accuracy of structure-based sequence alignment of automatic methods
Background: Accurate sequence alignments are essential for homology searches and for building three-dimensional structural models of proteins. Since structure is better conserved ...
Changhoon Kim, Byungkook Lee
156
Voted
BMCBI
2006
115views more  BMCBI 2006»
15 years 3 months ago
The accuracy of several multiple sequence alignment programs for proteins
Background: There have been many algorithms and software programs implemented for the inference of multiple sequence alignments of protein and DNA sequences. The "true" ...
Paulo A. S. Nuin, Zhouzhi Wang, Elisabeth R. M. Ti...
141
Voted
BMCBI
2006
134views more  BMCBI 2006»
15 years 3 months ago
A statistical score for assessing the quality of multiple sequence alignments
Background: Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein...
Virpi Ahola, Tero Aittokallio, Mauno Vihinen, Esa ...
141
Voted
BMCBI
2008
149views more  BMCBI 2008»
15 years 3 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal