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BMCBI
2008
100views more  BMCBI 2008»
14 years 9 months ago
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen p
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherap...
Guanglan Zhang, Asif M. Khan, Kellathur N. Sriniva...
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DATAMINE
2008
137views more  DATAMINE 2008»
14 years 9 months ago
Two heads better than one: pattern discovery in time-evolving multi-aspect data
Abstract. Data stream values are often associated with multiple aspects. For example, each value observed at a given time-stamp from environmental sensors may have an associated ty...
Jimeng Sun, Charalampos E. Tsourakakis, Evan Hoke,...
BMCBI
2006
152views more  BMCBI 2006»
14 years 9 months ago
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
Richard J. B. Dobson, Patricia B. Munroe, Mark J. ...
BMCBI
2006
130views more  BMCBI 2006»
14 years 9 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
BMCBI
2006
100views more  BMCBI 2006»
14 years 9 months ago
Empirical array quality weights in the analysis of microarray data
Background: Assessment of array quality is an essential step in the analysis of data from microarray experiments. Once detected, less reliable arrays are typically excluded or &qu...
Matthew E. Ritchie, Dileepa S. Diyagama, Jody Neil...