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108
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BMCBI
2008
142views more  BMCBI 2008»
15 years 24 days ago
Genetic weighted k-means algorithm for clustering large-scale gene expression data
Background: The traditional (unweighted) k-means is one of the most popular clustering methods for analyzing gene expression data. However, it suffers three major shortcomings. It...
Fang-Xiang Wu
BMCBI
2007
237views more  BMCBI 2007»
15 years 24 days ago
FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data
Background: Data clustering analysis has been extensively applied to extract information from gene expression profiles obtained with DNA microarrays. To this aim, existing cluster...
Limin Fu, Enzo Medico
113
Voted
BMCBI
2008
148views more  BMCBI 2008»
15 years 24 days ago
StAR: a simple tool for the statistical comparison of ROC curves
Background: As in many different areas of science and technology, most important problems in bioinformatics rely on the proper development and assessment of binary classifiers. A ...
Ismael A. Vergara, Tomás Norambuena, Evandr...
107
Voted
BMCBI
2010
117views more  BMCBI 2010»
15 years 24 days ago
Automatic, context-specific generation of Gene Ontology slims
Background: The use of ontologies to control vocabulary and structure annotation has added value to genomescale data, and contributed to the capture and re-use of knowledge across...
Melissa J. Davis, Muhammad Shoaib B. Sehgal, Mark ...
114
Voted
BMCBI
2008
104views more  BMCBI 2008»
15 years 24 days ago
Missing value imputation improves clustering and interpretation of gene expression microarray data
Background: Missing values frequently pose problems in gene expression microarray experiments as they can hinder downstream analysis of the datasets. While several missing value i...
Johannes Tuikkala, Laura Elo, Olli Nevalainen, Ter...
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