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» On Granular Knowledge Structures
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145
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BMCBI
2010
176views more  BMCBI 2010»
15 years 3 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...
142
Voted
BMCBI
2010
118views more  BMCBI 2010»
15 years 3 months ago
From learning taxonomies to phylogenetic learning: Integration of 16S rRNA gene data into FAME-based bacterial classification
Background: Machine learning techniques have shown to improve bacterial species classification based on fatty acid methyl ester (FAME) data. Nonetheless, FAME analysis has a limit...
Bram Slabbinck, Willem Waegeman, Peter Dawyndt, Pa...
121
Voted
BMCBI
2010
110views more  BMCBI 2010»
15 years 3 months ago
OLS Dialog: An open-source front end to the Ontology Lookup Service
Background: With the growing amount of biomedical data available in public databases it has become increasingly important to annotate data in a consistent way in order to allow ea...
Harald Barsnes, Richard G. Côté, Ingv...
103
Voted
BMCBI
2010
105views more  BMCBI 2010»
15 years 3 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
141
Voted
BMCBI
2008
122views more  BMCBI 2008»
15 years 3 months ago
Generating samples for association studies based on HapMap data
Background: With the completion of the HapMap project, a variety of computational algorithms and tools have been proposed for haplotype inference, tag SNP selection and genome-wid...
Jing Li, Yixuan Chen