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BMCBI
2010
144views more  BMCBI 2010»
14 years 12 months ago
Identifying overrepresented concepts in gene lists from literature: a statistical approach based on Poisson mixture model
Background: Large-scale genomic studies often identify large gene lists, for example, the genes sharing the same expression patterns. The interpretation of these gene lists is gen...
Xin He, Moushumi Sen Sarma, Xu Ling, Brant W. Chee...
91
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BMCBI
2010
117views more  BMCBI 2010»
14 years 12 months ago
New decoding algorithms for Hidden Markov Models using distance measures on labellings
Background: Existing hidden Markov model decoding algorithms do not focus on approximately identifying the sequence feature boundaries. Results: We give a set of algorithms to com...
Daniel G. Brown 0001, Jakub Truszkowski
90
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BMCBI
2010
109views more  BMCBI 2010»
14 years 12 months ago
Functional characterization and topological modularity of molecular interaction networks
Background: Analyzing interaction networks for functional characterization poses significant challenges arising from the noisy, incomplete, and generic nature of both the interact...
Jayesh Pandey, Mehmet Koyutürk, Ananth Grama
BMCBI
2007
139views more  BMCBI 2007»
14 years 12 months ago
XSTREAM: A practical algorithm for identification and architecture modeling of tandem repeats in protein sequences
Background: Biological sequence repeats arranged in tandem patterns are widespread in DNA and proteins. While many software tools have been designed to detect DNA tandem repeats (...
Aaron M. Newman, James B. Cooper
BMCBI
2008
178views more  BMCBI 2008»
14 years 12 months ago
A discriminative method for protein remote homology detection and fold recognition combining Top-n-grams and latent semantic ana
Background: Protein remote homology detection and fold recognition are central problems in bioinformatics. Currently, discriminative methods based on support vector machine (SVM) ...
Bin Liu, Xiaolong Wang, Lei Lin, Qiwen Dong, Xuan ...