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» On Suboptimal Alignments of Biological Sequences
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RECOMB
2003
Springer
16 years 2 months ago
Designing seeds for similarity search in genomic DNA
Large-scale comparison of genomic DNA is of fundamental importance in annotating functional elements of genomes. To perform large comparisons efficiently, BLAST (Methods: Companio...
Jeremy Buhler, Uri Keich, Yanni Sun
WABI
2009
Springer
142views Bioinformatics» more  WABI 2009»
15 years 8 months ago
Back-Translation for Discovering Distant Protein Homologies
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
Marta Gîrdea, Laurent Noé, Gregory Ku...
RECOMB
2010
Springer
14 years 11 months ago
Novel Definition and Algorithm for Chaining Fragments with Proportional Overlaps
Chaining fragments is a crucial step in genome alignment. Existing chaining algorithms compute a maximum weighted chain with no overlaps allowed between adjacent fragments. In prac...
Raluca Uricaru, Alban Mancheron, Eric Rivals
121
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SAC
2009
ACM
15 years 8 months ago
A new protein motif extraction framework based on constrained co-clustering
Signal finding (pattern discovery) in biological sequences is a fundamental problem in both computer science and molecular biology. Many approaches have been proposed for extract...
Francesca Cordero, Alessia Visconti, Marco Botta
VLSISP
2010
119views more  VLSISP 2010»
14 years 8 months ago
Hardware Acceleration of HMMER on FPGAs
We propose a new parallelization scheme for the hmmsearch function of the HMMER software, in order to target FPGA technology. hmmsearch is a very compute intensive software for bio...
Steven Derrien, Patrice Quinton