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» On Suboptimal Alignments of Biological Sequences
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BMCBI
2011
14 years 9 months ago
PICS-Ord: Unlimited Coding of Ambiguous Regions by Pairwise Identity and Cost Scores Ordination
Background: We present a novel method to encode ambiguously aligned regions in fixed multiple sequence alignments by ‘Pairwise Identity and Cost Scores Ordination’ (PICS-Ord)....
Robert K. Luecking, Brendan P. Hodkinson, Alexandr...
BMCBI
2004
208views more  BMCBI 2004»
15 years 1 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
ISMB
1993
15 years 3 months ago
Detection of Correlations in tRNA Sequences with Structural Implications
Using a flexible representation of biological sequences, we have performed a comparative analysis of 1208 known tRNA sequences. We believe we our technique is a more sensitive met...
Tod M. Klingler, Douglas L. Brutlag
BMCBI
2004
125views more  BMCBI 2004»
15 years 1 months ago
A functional hierarchical organization of the protein sequence space
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
Noam Kaplan, Moriah Friedlich, Menachem Fromer, Mi...
SC
2003
ACM
15 years 7 months ago
A Million-Fold Speed Improvement in Genomic Repeats Detection
This paper presents a novel, parallel algorithm for generating top alignments. Top alignments are used for finding internal repeats in biological sequences like proteins and gene...
John W. Romein, Jaap Heringa, Henri E. Bal