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» On error-tolerant DNA screening
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BMCBI
2007
88views more  BMCBI 2007»
14 years 9 months ago
Use of DNA melting simulation software for in silico diagnostic assay design: targeting regions with complex melting curves and
Background: DNA melting curve analysis using double-stranded DNA-specific dyes such as SYTO9 produce complex and reproducible melting profiles, resulting in the detection of multi...
John P. Rasmussen, Christopher P. Saint, Paul T. M...
BMCBI
2004
158views more  BMCBI 2004»
14 years 9 months ago
A novel Mixture Model Method for identification of differentially expressed genes from DNA microarray data
Background: The main goal in analyzing microarray data is to determine the genes that are differentially expressed across two types of tissue samples or samples obtained under two...
Kayvan Najarian, Maryam Zaheri, Ali Ajdari Rad, Si...
69
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IJBRA
2007
57views more  IJBRA 2007»
14 years 9 months ago
Decoding algorithms in pooling designs with inhibitors and error-tolerance
: Pooling designs are used in DNA library screening to efficiently distinguish positive from negative clones, which is fundamental for studying gene functions and many other biolog...
My T. Thai, David MacCallum, Ping Deng, Weili Wu
82
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CSB
2003
IEEE
15 years 2 months ago
Initial Large-scale Exploration of Protein-protein Interactions in Human Brain
Study of protein interaction networks is crucial to post-genomic systems biology. Aided by highthroughput screening technologies, biologists are rapidly accumulating protein-prote...
Jake Yue Chen, Andrey Y. Sivachenko, Russell Bell,...
TITB
2008
109views more  TITB 2008»
14 years 9 months ago
Automatic Segmentation of High-Throughput RNAi Fluorescent Cellular Images
High throughput genome-wide RNAi screening is emerging as an essential tool to assist biologists in understanding complex cellular processes. The large number of images produced in...
Pingkun Yan, Xiaobo Zhou, Mubarak Shah, Stephen T....