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» On the Brittleness of Evolutionary Algorithms
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CEC
2010
IEEE
14 years 11 months ago
Many-objective Distinct Candidates Optimization using Differential Evolution on centrifugal pump design problems
Many-objective problems are difficult to solve using conventional multi-objective evolutionary algorithms (MOEAs) as these algorithms rely primarily on Pareto ranking to guide the ...
Peter Dueholm Justesen, Rasmus K. Ursem
BMCBI
2010
176views more  BMCBI 2010»
14 years 10 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...
BMCBI
2007
175views more  BMCBI 2007»
14 years 10 months ago
CLUSS: Clustering of protein sequences based on a new similarity measure
Background: The rapid burgeoning of available protein data makes the use of clustering within families of proteins increasingly important. The challenge is to identify subfamilies...
Abdellali Kelil, Shengrui Wang, Ryszard Brzezinski...
BMCBI
2006
102views more  BMCBI 2006»
14 years 10 months ago
Protein secondary structure prediction for a single-sequence using hidden semi-Markov models
Background: The accuracy of protein secondary structure prediction has been improving steadily towards the 88% estimated theoretical limit. There are two types of prediction algor...
Zafer Aydin, Yucel Altunbasak, Mark Borodovsky
BMCBI
2005
94views more  BMCBI 2005»
14 years 10 months ago
YANA - a software tool for analyzing flux modes, gene-expression and enzyme activities
Background: A number of algorithms for steady state analysis of metabolic networks have been developed over the years. Of these, Elementary Mode Analysis (EMA) has proven especial...
Roland Schwarz, Patrick Musch, Axel von Kamp, Bern...