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BMCBI
2005
106views more  BMCBI 2005»
14 years 9 months ago
A multistep bioinformatic approach detects putative regulatory elements in gene promoters
Background: Searching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge ...
Stefania Bortoluzzi, Alessandro Coppe, Andrea Biso...
BMCBI
2005
161views more  BMCBI 2005»
14 years 9 months ago
Non-linear mapping for exploratory data analysis in functional genomics
Background: Several supervised and unsupervised learning tools are available to classify functional genomics data. However, relatively less attention has been given to exploratory...
Francisco Azuaje, Haiying Wang, Alban Chesneau
BMCBI
2005
112views more  BMCBI 2005»
14 years 9 months ago
Visualization methods for statistical analysis of microarray clusters
Background: The most common method of identifying groups of functionally related genes in microarray data is to apply a clustering algorithm. However, it is impossible to determin...
Matthew A. Hibbs, Nathaniel C. Dirksen, Kai Li, Ol...
BMCBI
2005
163views more  BMCBI 2005»
14 years 9 months ago
Rank-invariant resampling based estimation of false discovery rate for analysis of small sample microarray data
Background: The evaluation of statistical significance has become a critical process in identifying differentially expressed genes in microarray studies. Classical p-value adjustm...
Nitin Jain, HyungJun Cho, Michael O'Connell, Jae K...
BMCBI
2005
94views more  BMCBI 2005»
14 years 9 months ago
Visualization-based discovery and analysis of genomic aberrations in microarray data
Background: Chromosomal copy number changes (aneuploidies) play a key role in cancer progression and molecular evolution. These copy number changes can be studied using microarray...
Chad L. Myers, Xing Chen, Olga G. Troyanskaya