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» On the Multiple Gene Duplication Problem
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CCE
2008
15 years 1 months ago
Informative gene selection and design of regulatory networks using integer optimization
A central problem in bioinformatics and systems biology is the selection of appropriate models in a rational and systematic way. This fundamentally combinatorial problem can be re...
Eric Yang, Timothy Maguire, Martin L. Yarmush, Ioa...
ISBRA
2009
Springer
15 years 8 months ago
Prediction of Contiguous Regions in the Amniote Ancestral Genome
Abstract. We investigate the problem of inferring contiguous ancestral regions (CARs) of the genome of the last common ancestor of all extant amniotes, based on the currently seque...
Aïda Ouangraoua, Frédéric Boyer...
110
Voted
RECOMB
2006
Springer
16 years 2 months ago
A Parsimony Approach to Genome-Wide Ortholog Assignment
The assignment of orthologous genes between a pair of genomes is a fundamental and challenging problem in comparative genomics, since many computational methods for solving various...
Zheng Fu, Xin Chen, Vladimir Vacic, Peng Nan, Yang...
BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
15 years 8 months ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber
119
Voted
JIFS
2002
134views more  JIFS 2002»
15 years 1 months ago
Classification of gene expression data using fuzzy logic
Microarray technologies have allowed the measurement of expression of multiple genes simultaneously. Gene expression levels can be used to classify tissues into diagnostic or progn...
Lucila Ohno-Machado, Staal A. Vinterbo, Griffin We...