A central problem in bioinformatics and systems biology is the selection of appropriate models in a rational and systematic way. This fundamentally combinatorial problem can be re...
Eric Yang, Timothy Maguire, Martin L. Yarmush, Ioa...
Abstract. We investigate the problem of inferring contiguous ancestral regions (CARs) of the genome of the last common ancestor of all extant amniotes, based on the currently seque...
The assignment of orthologous genes between a pair of genomes is a fundamental and challenging problem in comparative genomics, since many computational methods for solving various...
Zheng Fu, Xin Chen, Vladimir Vacic, Peng Nan, Yang...
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Microarray technologies have allowed the measurement of expression of multiple genes simultaneously. Gene expression levels can be used to classify tissues into diagnostic or progn...
Lucila Ohno-Machado, Staal A. Vinterbo, Griffin We...