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» On the Multiple Gene Duplication Problem
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BMCBI
2006
137views more  BMCBI 2006»
14 years 11 months ago
Sigma: multiple alignment of weakly-conserved non-coding DNA sequence
Background: Existing tools for multiple-sequence alignment focus on aligning protein sequence or protein-coding DNA sequence, and are often based on extensions to Needleman-Wunsch...
Rahul Siddharthan
BMCBI
2005
104views more  BMCBI 2005»
14 years 11 months ago
A statistical approach for array CGH data analysis
Background: Microarray-CGH experiments are used to detect and map chromosomal imbalances, by hybridizing targets of genomic DNA from a test and a reference sample to sequences imm...
Franck Picard, Stéphane Robin, Marc Laviell...
BMCBI
2008
76views more  BMCBI 2008»
14 years 12 months ago
Empirical Bayes analysis of single nucleotide polymorphisms
Background: An important goal of whole-genome studies concerned with single nucleotide polymorphisms (SNPs) is the identification of SNPs associated with a covariate of interest s...
Holger Schwender, Katja Ickstadt
TCBB
2008
95views more  TCBB 2008»
14 years 11 months ago
Solving the Problem of Trans-Genomic Query with Alignment Tables
Abstract-- The trans-genomic query (TGQ) problem -- enabling the free query of biological information, even across genomes -- is a central challenge facing bioinformatics. Solution...
Douglas Stott Parker Jr., Ruey-Lung Hsiao, Yi Xing...
BMCBI
2006
139views more  BMCBI 2006»
14 years 11 months ago
Improvement in accuracy of multiple sequence alignment using novel group-to-group sequence alignment algorithm with piecewise li
Background: Multiple sequence alignment (MSA) is a useful tool in bioinformatics. Although many MSA algorithms have been developed, there is still room for improvement in accuracy...
Shinsuke Yamada, Osamu Gotoh, Hayato Yamana