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» On the Notion of Value Object
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BMCBI
2010
95views more  BMCBI 2010»
15 years 26 days ago
Spatio-structural granularity of biological material entities
Background: With the continuously increasing demands on knowledge- and data-management that databases have to meet, ontologies and the theories of granularity they use become more...
Lars Vogt
BMCBI
2007
120views more  BMCBI 2007»
15 years 26 days ago
Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures
Background: When conducting multiple hypothesis tests, it is important to control the number of false positives, or the False Discovery Rate (FDR). However, there is a tradeoff be...
Xin Lu, David L. Perkins
113
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BMCBI
2007
162views more  BMCBI 2007»
15 years 26 days ago
Three-Dimensional Phylogeny Explorer: Distinguishing paralogs, lateral transfer, and violation of "molecular clock" assumption w
Background: Construction and interpretation of phylogenetic trees has been a major research topic for understanding the evolution of genes. Increases in sequence data and complexi...
Namshin Kim, Christopher Lee
96
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BMCBI
2007
101views more  BMCBI 2007»
15 years 26 days ago
Relationship between insertion/deletion (indel) frequency of proteins and essentiality
Background: In a previous study, we demonstrated that some essential proteins from pathogenic organisms contained sizable insertions/deletions (indels) when aligned to human prote...
Simon K. Chan, Michael Hsing, Fereydoun Hormozdiar...
112
Voted
BMCBI
2007
132views more  BMCBI 2007»
15 years 26 days ago
On the analysis of glycomics mass spectrometry data via the regularized area under the ROC curve
Background: Novel molecular and statistical methods are in rising demand for disease diagnosis and prognosis with the help of recent advanced biotechnology. High-resolution mass s...
Jingjing Ye, Hao Liu, Crystal Kirmiz, Carlito B. L...