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» On the Optimality of Spiral Search
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BMCBI
2006
119views more  BMCBI 2006»
14 years 11 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs
95
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BMCBI
2006
95views more  BMCBI 2006»
14 years 11 months ago
Discrete profile comparison using information bottleneck
Sequence homologs are an important source of information about proteins. Amino acid profiles, representing the position-specific mutation probabilities found in profiles, are a ri...
Sean O'Rourke, Gal Chechik, Robin Friedman, Eleaza...
BMCBI
2006
130views more  BMCBI 2006»
14 years 11 months ago
Docking protein domains in contact space
Background: Many biological processes involve the physical interaction between protein domains. Understanding these functional associations requires knowledge of the molecular str...
Stefano Lise, Alice Walker-Taylor, David T. Jones
100
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BMCBI
2006
153views more  BMCBI 2006»
14 years 11 months ago
Automatic document classification of biological literature
Background: Document classification is a wide-spread problem with many applications, from organizing search engine snippets to spam filtering. We previously described Textpresso, ...
David Chen, Hans-Michael Müller, Paul W. Ster...
85
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CLASSIFICATION
2006
108views more  CLASSIFICATION 2006»
14 years 11 months ago
The Practice of Cluster Analysis
Abstracts "Mixtures at the Interface" David Scott, Rice University Mixture modeling provides an effective framework for complex, high-dimensional data. The potential of m...
Jon R. Kettenring