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» On the Role of Integrity Constraints in Data Integration
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BMCBI
2008
105views more  BMCBI 2008»
14 years 9 months ago
Novel computational methods for increasing PCR primer design effectiveness in directed sequencing
Background: Polymerase chain reaction (PCR) is used in directed sequencing for the discovery of novel polymorphisms. As the first step in PCR directed sequencing, effective PCR pr...
Kelvin Li, Anushka Brownley, Timothy B. Stockwell,...
BMCBI
2008
133views more  BMCBI 2008»
14 years 9 months ago
Towards ontology-driven navigation of the lipid bibliosphere
Background: The indexing of scientific literature and content is a relevant and contemporary requirement within life science information systems. Navigating information available ...
Christopher J. O. Baker, Kanagasabai Rajaraman, We...
BMCBI
2006
142views more  BMCBI 2006»
14 years 9 months ago
Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with
Background: Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several ...
Angela Re, Davide Corà, Alda Maria Puliti, ...
BMCBI
2006
144views more  BMCBI 2006»
14 years 9 months ago
methBLAST and methPrimerDB: web-tools for PCR based methylation analysis
Background: DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methy...
Filip Pattyn, Jasmien Hoebeeck, Piet Robbrecht, Ev...
BMCBI
2011
14 years 1 months ago
RAG: An Update to the RNA-As-Graphs Resource
Background: In 2004, we presented a web resource for stimulating the search for novel RNAs, RNA-As-Graphs (RAG), which classified, catalogued, and predicted RNA secondary structur...
Joseph A. Izzo, Namhee Kim, Shereef Elmetwaly, Tam...