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113
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BMCBI
2004
196views more  BMCBI 2004»
15 years 19 days ago
MUSCLE: a multiple sequence alignment method with reduced time and space complexity
Background: In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUS...
Robert C. Edgar
BMCBI
2004
206views more  BMCBI 2004»
15 years 19 days ago
Combining gene expression data from different generations of oligonucleotide arrays
Background: One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public re...
Kyu Baek Hwang, Sek Won Kong, Steven A. Greenberg,...
107
Voted
BMCBI
2004
139views more  BMCBI 2004»
15 years 19 days ago
mlstdbNet - distributed multi-locus sequence typing (MLST) databases
Background: Multi-locus sequence typing (MLST) is a method of typing that facilitates the discrimination of microbial isolates by comparing the sequences of housekeeping gene frag...
Keith A. Jolley, Man-Suen Chan, Martin C. J. Maide...
115
Voted
BMCBI
2004
88views more  BMCBI 2004»
15 years 19 days ago
Coronavirus 3CLpro proteinase cleavage sites: Possible relevance to SARS virus pathology
Background: Despite the passing of more than a year since the first outbreak of Severe Acute Respiratory Syndrome (SARS), efficient counter-measures are still few and many believe...
Lars Kiemer, Ole Lund, Søren Brunak, Nikola...
99
Voted
BMCBI
2004
96views more  BMCBI 2004»
15 years 19 days ago
Gene finding in novel genomes
Background: Computational gene prediction continues to be an important problem, especially for genomes with little experimental data. Results: I introduce the SNAP gene finder whi...
Ian Korf
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