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» On the monotonization of the training set
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101
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BMCBI
2010
116views more  BMCBI 2010»
15 years 22 days ago
FiGS: a filter-based gene selection workbench for microarray data
Background: The selection of genes that discriminate disease classes from microarray data is widely used for the identification of diagnostic biomarkers. Although various gene sel...
Taeho Hwang, Choong-Hyun Sun, Taegyun Yun, Gwan-Su...
BMCBI
2010
105views more  BMCBI 2010»
15 years 22 days ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
125
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BMCBI
2007
149views more  BMCBI 2007»
15 years 22 days ago
A unified framework for finding differentially expressed genes from microarray experiments
Background: This paper presents a unified framework for finding differentially expressed genes (DEGs) from the microarray data. The proposed framework has three interrelated modul...
Jahangheer S. Shaik, Mohammed Yeasin
122
Voted
BMCBI
2008
202views more  BMCBI 2008»
15 years 22 days ago
Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data
Background: Integrating data from multiple global assays and curated databases is essential to understand the spatiotemporal interactions within cells. Different experiments measu...
Yuji Zhang, Jianhua Xuan, Benildo de los Reyes, Ro...
90
Voted
BMCBI
2007
94views more  BMCBI 2007»
15 years 22 days ago
False positive reduction in protein-protein interaction predictions using gene ontology annotations
Background: Many crucial cellular operations such as metabolism, signalling, and regulations are based on protein-protein interactions. However, the lack of robust protein-protein...
Mahmood A. Mahdavi, Yen-Han Lin