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BMCBI
2011
14 years 4 months ago
Identifying hypermethylated CpG islands using a quantile regression model
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
Shuying Sun, Zhengyi Chen, Pearlly Yan, Yi-Wen Hua...
ECAI
2010
Springer
14 years 7 months ago
Describing the Result of a Classifier to the End-User: Geometric-based Sensitivity
This paper addresses the issue of supporting the end-user of a classifier, when it is used as a decision support system, to classify new cases. We consider several kinds of classif...
Isabelle Alvarez, Sophie Martin, Salma Mesmoudi
BMCBI
2010
155views more  BMCBI 2010»
14 years 9 months ago
A bi-ordering approach to linking gene expression with clinical annotations in gastric cancer
Background: In the study of cancer genomics, gene expression microarrays, which measure thousands of genes in a single assay, provide abundant information for the investigation of...
Fan Shi, Christopher Leckie, Geoff MacIntyre, Izha...
FLAIRS
2004
14 years 11 months ago
Gene Expression Data Classification with Revised Kernel Partial Least Squares Algorithm
One important feature of the gene expression data is that the number of genes M far exceeds the number of samples N. Standard statistical methods do not work well when N < M. D...
ZhenQiu Liu, Dechang Chen
BMCBI
2006
170views more  BMCBI 2006»
14 years 9 months ago
Biclustering of gene expression data by non-smooth non-negative matrix factorization
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
Pedro Carmona-Saez, Roberto D. Pascual-Marqui, Fra...