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BMCBI
2007
142views more  BMCBI 2007»
15 years 3 months ago
Predicting and improving the protein sequence alignment quality by support vector regression
Background: For successful protein structure prediction by comparative modeling, in addition to identifying a good template protein with known structure, obtaining an accurate seq...
Minho Lee, Chan-seok Jeong, Dongsup Kim
BMCBI
2007
159views more  BMCBI 2007»
15 years 3 months ago
Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype
Background: A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level. Results: We ...
Israel Mark Martínez-Pérez, Gong Zha...
110
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BMCBI
2007
78views more  BMCBI 2007»
15 years 3 months ago
Improved human disease candidate gene prioritization using mouse phenotype
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
Jing Chen, Huan Xu, Bruce J. Aronow, Anil G. Jegga
BMCBI
2007
116views more  BMCBI 2007»
15 years 3 months ago
MED: a new non-supervised gene prediction algorithm for bacterial and archaeal genomes
Background: Despite a remarkable success in the computational prediction of genes in Bacteria and Archaea, a lack of comprehensive understanding of prokaryotic gene structures pre...
Huaiqiu Zhu, Gang-Qing Hu, Yi-Fan Yang, Jin Wang, ...
135
Voted
ESE
2006
105views Database» more  ESE 2006»
15 years 3 months ago
Replaying development history to assess the effectiveness of change propagation tools
As developers modify software entities such as functions or variables to introduce new features, enhance old ones, or fix bugs, they must ensure that other entities in the software...
Ahmed E. Hassan, Richard C. Holt
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