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BMCBI
2010
108views more  BMCBI 2010»
15 years 2 months ago
Predicting changes in protein thermostability brought about by single- or multi-site mutations
Background: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostabilit...
Jian Tian, Ningfeng Wu, Xiaoyu Chu, Yunliu Fan
136
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BMCBI
2007
147views more  BMCBI 2007»
15 years 2 months ago
Improved residue contact prediction using support vector machines and a large feature set
Background: Predicting protein residue-residue contacts is an important 2D prediction task. It is useful for ab initio structure prediction and understanding protein folding. In s...
Jianlin Cheng, Pierre Baldi
BMCBI
2008
79views more  BMCBI 2008»
15 years 2 months ago
A high-throughput pipeline for designing microarray-based pathogen diagnostic assays
Background: We present a methodology for high-throughput design of oligonucleotide fingerprints for microarray-based pathogen diagnostic assays. The oligonucleotide fingerprints, ...
Ravi Vijaya Satya, Nela Zavaljevski, Kamal Kumar, ...
BMCBI
2008
105views more  BMCBI 2008»
15 years 2 months ago
A Bayesian method for calculating real-time quantitative PCR calibration curves using absolute plasmid DNA standards
Background: In real-time quantitative PCR studies using absolute plasmid DNA standards, a calibration curve is developed to estimate an unknown DNA concentration. However, potenti...
Mano Sivaganesan, Shawn Seifring, Manju Varma, Ric...
BMCBI
2007
139views more  BMCBI 2007»
15 years 2 months ago
XSTREAM: A practical algorithm for identification and architecture modeling of tandem repeats in protein sequences
Background: Biological sequence repeats arranged in tandem patterns are widespread in DNA and proteins. While many software tools have been designed to detect DNA tandem repeats (...
Aaron M. Newman, James B. Cooper
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