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» Optimal detection of sequence similarity by local alignment
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RECOMB
1998
Springer
15 years 2 months ago
Optimal detection of sequence similarity by local alignment
Terence Hwa, Michael Lässig
76
Voted
JCB
2000
91views more  JCB 2000»
14 years 10 months ago
Scaling Laws and Similarity Detection in Sequence Alignment with Gaps
We study the problem of similarity detection by sequence alignment with gaps, using a recently established theoretical framework based on the morphology of alignment paths. Alignm...
Dirk Drasdo, Terence Hwa, Michael Lässig
86
Voted
BMCBI
2006
120views more  BMCBI 2006»
14 years 10 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu
80
Voted
BMCBI
2010
137views more  BMCBI 2010»
14 years 10 months ago
Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments
Background: While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor ...
Michael L. Sierk, Michael E. Smoot, Ellen J. Bass,...
87
Voted
BMCBI
2010
147views more  BMCBI 2010»
14 years 10 months ago
Automatic detection of anchor points for multiple sequence alignment
Background: Determining beforehand specific positions to align (anchor points) has proved valuable for the accuracy of automated multiple sequence alignment (MSA) software. This f...
Florian Pitschi, Claudine Devauchelle, Eduardo Cor...