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141
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BMCBI
2006
239views more  BMCBI 2006»
15 years 3 months ago
Applying dynamic Bayesian networks to perturbed gene expression data
Background: A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics,...
Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek...
126
Voted
HEURISTICS
2008
124views more  HEURISTICS 2008»
15 years 3 months ago
A variable neighborhood search for the capacitated arc routing problem with intermediate facilities
In this talk we present a unified Variable Neighborhood Search (VNS) algorithm for the Capacitated Arc Routing Problem (CARP) and some of its variants - the Capacitated Arc Routin...
Michael Polacek, Karl F. Doerner, Richard F. Hartl...
137
Voted
BMCBI
2006
100views more  BMCBI 2006»
15 years 3 months ago
Using the nucleotide substitution rate matrix to detect horizontal gene transfer
Background: Horizontal gene transfer (HGT) has allowed bacteria to evolve many new capabilities. Because transferred genes perform many medically important functions, such as conf...
Micah Hamady, M. D. Betterton, Rob Knight
116
Voted
BMCBI
2006
60views more  BMCBI 2006»
15 years 3 months ago
Use of a multi-way method to analyze the amino acid composition of a conserved group of orthologous proteins in prokaryotes
Background: Amino acids in proteins are not used equally. Some of the differences in the amino acid composition of proteins are between species (mainly due to nucleotide compositi...
Alberto Pasamontes, Santiago Garcia-Vallvé
151
Voted
BMCBI
2006
137views more  BMCBI 2006»
15 years 3 months ago
Bounded search for de novo identification of degenerate cis-regulatory elements
Background: The identification of statistically overrepresented sequences in the upstream regions of coregulated genes should theoretically permit the identification of potential ...
Jonathan M. Carlson, Arijit Chakravarty, Radhika S...
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