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BMCBI
2010
116views more  BMCBI 2010»
15 years 5 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
SIAMJO
2008
212views more  SIAMJO 2008»
15 years 4 months ago
Convergence Rate of an Optimization Algorithm for Minimizing Quadratic Functions with Separable Convex Constraints
A new active set algorithm for minimizing quadratic functions with separable convex constraints is proposed by combining the conjugate gradient method with the projected gradient. ...
Radek Kucera
VLDB
1998
ACM
86views Database» more  VLDB 1998»
15 years 9 months ago
Inferring Function Semantics to Optimize Queries
The goal of the COKO-KOLA project [10, 91 is to express rules of rule-basedoptimizers in a mannerpermitting verification with a theoremprover. In [IO], we consideredquerytransform...
Mitch Cherniack, Stanley B. Zdonik
ICC
2009
IEEE
110views Communications» more  ICC 2009»
15 years 11 months ago
Delay Constrained Scheduling over Fading Channels: Optimal Policies for Monomial Energy-Cost Functions
— A point-to-point discrete-time scheduling problem of transmitting B information bits within T hard delay deadline slots is considered assuming that the underlying energy-bit co...
Juyul Lee, Nihar Jindal
DATE
2000
IEEE
130views Hardware» more  DATE 2000»
15 years 9 months ago
Optimal Hardware Pattern Generation for Functional BIST
∗∗ Functional BIST is a promising solution for self-testing complex digital systems at reduced costs in terms of area and performance degradation. The present paper addresses t...
Silvia Cataldo, Silvia Chiusano, Paolo Prinetto, H...