The cost of reachability query computation using traditional algorithms such as depth first search or transitive closure has been found to be prohibitive and unacceptable in mass...
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
Background: With next-generation sequencing technologies, experiments that were considered prohibitive only a few years ago are now possible. However, while these technologies hav...
Osvaldo Zagordi, Arnab Bhattacharya, Nicholas Erik...
Background: Statistical methods for ranking differentially expressed genes (DEGs) from gene expression data should be evaluated with regard to high sensitivity, specificity, and r...