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CIKM
2010
Springer
15 years 11 days ago
A hierarchical approach to reachability query answering in very large graph databases
The cost of reachability query computation using traditional algorithms such as depth first search or transitive closure has been found to be prohibitive and unacceptable in mass...
Saikat K. Dey, Hasan M. Jamil
WABI
2010
Springer
167views Bioinformatics» more  WABI 2010»
15 years 3 days ago
Quantifying the Strength of Natural Selection of a Motif Sequence
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Chen-Hsiang Yeang
BMCBI
2010
123views more  BMCBI 2010»
14 years 8 months ago
Predicting conserved protein motifs with Sub-HMMs
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
Kevin Horan, Christian R. Shelton, Thomas Girke
BMCBI
2011
14 years 5 months ago
ShoRAH: estimating the genetic diversity of a mixed sample from next-generation sequencing data
Background: With next-generation sequencing technologies, experiments that were considered prohibitive only a few years ago are now possible. However, while these technologies hav...
Osvaldo Zagordi, Arnab Bhattacharya, Nicholas Erik...
BMCBI
2011
14 years 5 months ago
Evaluating methods for ranking differentially expressed genes applied to MicroArray Quality Control data
Background: Statistical methods for ranking differentially expressed genes (DEGs) from gene expression data should be evaluated with regard to high sensitivity, specificity, and r...
Koji Kadota, Kentaro Shimizu