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BMCBI
2010
83views more  BMCBI 2010»
14 years 9 months ago
Trees on networks: resolving statistical patterns of phylogenetic similarities among interacting proteins
Background: Phylogenies capture the evolutionary ancestry linking extant species. Correlations and similarities among a set of species are mediated by and need to be understood in...
William P. Kelly, Michael P. H. Stumpf
JCB
2002
131views more  JCB 2002»
14 years 9 months ago
Modeling and Simulation of Genetic Regulatory Systems: A Literature Review
In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The reg...
Hidde de Jong
BMCBI
2006
145views more  BMCBI 2006»
14 years 9 months ago
GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
Kazuharu Arakawa, Yohei Yamada, Kosaku Shinoda, Yo...
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RECOMB
2010
Springer
15 years 4 months ago
Incremental Signaling Pathway Modeling by Data Integration
Constructing quantitative dynamic models of signaling pathways is an important task for computational systems biology. Pathway model construction is often an inherently incremental...
Geoffrey Koh, David Hsu, P. S. Thiagarajan
BIODATAMINING
2008
119views more  BIODATAMINING 2008»
14 years 9 months ago
A survey of visualization tools for biological network analysis
The analysis and interpretation of relationships between biological molecules, networks and concepts is becoming a major bottleneck in systems biology. Very often the pure amount ...
Georgios A. Pavlopoulos, Anna-Lynn Wegener, Reinha...