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BMCBI
2006
172views more  BMCBI 2006»
14 years 10 months ago
BioWarehouse: a bioinformatics database warehouse toolkit
Background: This article addresses the problem of interoperation of heterogeneous bioinformatics databases. Results: We introduce BioWarehouse, an open source toolkit for construc...
Thomas J. Lee, Yannick Pouliot, Valerie Wagner, Pr...
ISDA
2006
IEEE
15 years 4 months ago
From Gene to Drug: A Proof of Concept for a Plausible Computational Pathway
The last decade has witnessed an exponential growth of sequence information in the field of biological macromolecules such as proteins and nucleic acids and their interactions wit...
Sandhya Shenoy, B. Jayaram, N. Latha, Pooja Narang...
BIBE
2008
IEEE
111views Bioinformatics» more  BIBE 2008»
14 years 12 months ago
Structure learning for biomolecular pathways containing cycles
Bayesian network structure learning is a useful tool for elucidation of regulatory structures of biomolecular pathways. The approach however is limited by its acyclicity constraint...
S. Itani, Karen Sachs, Garry P. Nolan, M. A. Dahle...
BMCBI
2008
159views more  BMCBI 2008»
14 years 10 months ago
Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via log
Background: Growing interest on biological pathways has called for new statistical methods for modeling and testing a genetic pathway effect on a health outcome. The fact that gen...
Dawei Liu, Debashis Ghosh, Xihong Lin
CSB
2005
IEEE
133views Bioinformatics» more  CSB 2005»
15 years 3 months ago
Biological Pathway Prediction from Multiple Data Sources Using Iterative Bayesian Updating
There is a diversity of functional genomics data, such as gene expression data from microarray experiments, phenotypic data from gene deletion experiments, protein-protein interac...
Corey Powell, Joshua M. Stuart