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ECCC
2008
14 years 10 months ago
2008
Any proof of P = NP will have to overcome two barriers: relativization and natural proofs. Yet over the last decade, we have seen circuit lower bounds (for example, that PP does n...
BMCBI
2006
2006
ZCURVE_V: a new self-training system for recognizing protein-coding genes in viral and phage genomes
14 years 10 months ago
Background: It necessary to use highly accurate and statistics-based systems for viral and phage genome annotations. The GeneMark systems for gene-finding in virus and phage genom...
BMCBI
2006
14 years 10 months ago
2006
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
BMCBI
2006
14 years 10 months ago
2006
Background: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule bindi...
BMCBI
2006
14 years 10 months ago
2006
Background: Understanding the relationship between gene expression changes, enzyme activity shifts, and the corresponding physiological adaptive response of organisms to environme...